Image standardization is an important preprocessing step in several image
processing applications. In neuroimaging, by reducing normal variability through the
standardization of brains, functional activity from multiple subjects can be overlaid to
study localization. Furthermore, variability outside normal ranges can be used to report
abnormalities. In automatic facial expression recognition, by standardizing the facial
features, the accuracy of the facial expression recognition can be increased. The current
standardization methods are mostly based on global alignment and warping strategies.
However, global standardization methods fail to align individual structures accurately.
In this study, we propose a feature-based, semi-automatic, non-parametric, and
non-linear standardization framework to complement the existing global methods. The
method consists of three phases: In phase one, templates are generated from the atlas
structures, using Self-Organizing Maps (SOMs). The parameters of each SOM are determined using a new topology evaluation technique. In phase two, the atlas templates
are reconfigured using points from individual features, to establish a one-to-one
correspondence between the atlas and individual structures. During training, a
regularization procedure can be optionally invoked to guarantee smoothness in areas
where the discrepancy between the atlas and individual feature is high. In the final phase,
difference vectors are generated using the corresponding points of the atlas and individual
structure. The whole image is warped by interpolation of the difference vectors through
Gaussian radial basis functions, which are determined by minimizing the membrane
energy.
Results are demonstrated on simulated features, as well as selected sulci in brain
MRIs, and facial features. There are two significant advantages of this system over the
existing standardization schemes: increased accuracy and speed in the alignment of
internal features. Although our framework does not handle standardization of global
shape and size differences, it can easily be used as a complementary module for the
existing global standardization techniques, to increase precision of local alignment. |