 oophorectomi cortison treatment method elimin oestrogen product patient breast cancer urinari excret oestron oestradiol-17b oestriol 17- hydroxycorticosteroid estim 55 premenopaus 91 postmenopaus women breast cancer stage diseas therapi deplet oestrogen excret caus oophorectomi combin cortison treatment studi patient metastasis breast tumour 32 premenopaus 56 postmenopaus subject patient dissemin breast cancer excret larger quantiti oestriol healthi women ag pre- postmenopaus excret oestron oestradiol-17b cancer patient healthi women correspond ag oophorectomi reduc oestrogen excret premenopaus subject number postmenopaus patient excret amount oestrogen decreas oestrogen output transient compensatori increas adren origin cortison administ month oophorectomi dosag 50 dai rapidli depress secondari rise oestrogen output level 4 5 ug 24 irrespect ag patient excret level unchang long cortison adequ dose increas rapidli cortison treatment discontinu oophorectomi combin adequ cortison treatment offer altern extens surgic porcedur undertaken elimin oestrogen product breast cancer patient 