 hormon therapi metastat breast cancer clinic respons urinari gonadotrophin total urinari gonadotrophin output group post menopaus women metastat breast carcinoma undergo hormon therapi case initi consist treatment diethylstilboestrol de 20 studi period vari month 31 2 year correl gonadotrophin output clinic respons case show object regress urinari gonadotrophin remain low remiss period low level gonadotrophin output indic good clinic remiss withdraw de independ period therapi recoveri pre-treatment level rule except small group patient maintain lower dose de 3-5 degre suppress urinari output receiv 20 exhibit object remiss studi emphasis site specif respons hormon therapi underlin difficulti relat clinic respons patient chang hormon environ 