 acut leukemia associ phenylbutazon treatment review literatur report case toxic reaction phenylbutazon list review literatur haematolog complic 16 death attribut agranulocytosi aplast anaemia thrombocytopenia record associ leukaemia phenylbutazon suggest bean 1960 amplifi report review case histori present 15 patient acut leukaemia associ record leukaemogen factor three three drug short time leukaemia diagnos remain histori phenylbutazon ingest associ develop leukaemia studi includ match control indic requir definit opinion causal relationship drug diseas 