 excret pattern urinari metabolit estradiol-4-c14 postmenopaus women benign malign diseas breast studi excret pattern urinari metabolit estradiol-4-c1j administ group 43 postmenopaus women 38 advanc mammari carcinoma prior endocrin therapi 5 benign mammari dysplasia report chromatograph method emploi determin estradiol estron estriol estrogen metabolit urinari excret pattern defin extent excret isotop 3 success 24-hr collect period percentag urinari radiometabolit enzymat hydrolyz rel concentr metabolit hydrolyz fraction wide subject-to-subject variat metabolit estradiol estron estriol compris larg portion total estrogen excret lower amount estradiol group women mammari carcinoma compar amount group women benign mammari dysplasia suggest group metabol rapidli administ estradiol excret pattern patient fail respond estrogen treatment nonrespond differ greatest pattern associ benign diseas distinct pattern urinari excret isotop estrogen allow statist clinic separ respond nonrespond subsequ estrogen therapi discov 